Stem Cells/Mesenchymal

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Charles Vacanti, Ph.D. of Mass General in Boston, MA discusses an experiment where an ear grown in vitro is grafted onto an immunosuppressed mouse. (This was the cover image of a Nature magazine in 1997)
Charles Vacanti, Ph.D. of Mass General in Boston, MA discusses an experiment where an ear grown in vitro is grafted onto an immunosuppressed mouse.[1] (This was the cover image of a Nature magazine in 1997)[2]

Contents

Introduction

Human mesenchymal stem cells (MSC) are spindle shaped, fibroblast-like cells. Original magnification × 100, phase-contrast light microscopy, scale bar represents 50 μm. Ryan et al. Journal of Inflammation 2005 2:8   doi:10.1186/1476-9255-2-8
Human mesenchymal stem cells (MSC) are spindle shaped, fibroblast-like cells. Original magnification × 100, phase-contrast light microscopy, scale bar represents 50 μm. Ryan et al. Journal of Inflammation 2005 2:8 doi:10.1186/1476-9255-2-8

Mesenchymal stem cells, or MSCs, which are found in the bone marrow, are multipotent stem cells that can differentiate into a variety of lineages including:[3][4]

  • cartilage
  • bone
  • muscle
  • tendon
  • ligament
  • brain
  • adipose tissue.[5]

Mesenchymal cells may be beneficial to stroke recovery

Stem Cells Heal Chronic Inflammation In The Gut - May Help Restore Immune System To Normal Function For Crohn's Disease

[7]

References

  1. http://www.youtube.com/watch?v=PEc7QXAjsL4&eurl=http%3A%2F%2Fwww.autismpedia.org%2Fwiki%2Findex.php%3Ftitle%3DStem_Cells%2FMesenchymal&feature=player_embedded
  2. http://photosthatchangedtheworld.com/mouse-with-human-ear/
  3. http://en.wikipedia.org/wiki/Mesenchymal_stem_cell
  4. http://www.journal-inflammation.com/content/2/1/8
  5. Lang, et. al, Contribution of Bone Marrow Hematopoietic Stem Cells to Adult Mouse Inner Ear: Mesenchymal Cells and Fibrocytes, J Comp Neurol. Author manuscript; available in PMC 2008 October 6. Published in final edited form as: J Comp Neurol. 2006 May 10; 496(2): 187–201. doi: 10.1002/cne.20929.
  6. Dezawa M, Hoshino M, Nabeshima Y, ide C. marrow stromal cells: implications in health and disease in the nervous sytem. Curr Mol Med 2005; 5(7): 723-32
  7. http://www.medicalnewstoday.com/articles/115175.php
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